Cooking spray or oil, for pan
2 tablespoons olive oil
1 medium onion, diced (about 1 cup)
3 garlic cloves, minced
1 tablespoon ancho chile powder
2 teaspoons cumin
1 teaspoon Mexican oregano or marjoram
2 generous splashes Worcestershire sauce
1 cup fresh bread crumbs
1 cup whole milk
2 pounds meatloaf mix
2 Anaheim chile peppers, roasted, seeded and chopped
11/2 cups shredded Monterey Jack, Pepper Jack or Mexican blend cheese
1/4 cup chopped fresh cilantro
1 large egg, beaten
2 teaspoons kosher salt
1 teaspoon black pepper
For glaze
1/4 cup ketchup
1/4 cup brown sugar
2 canned chipotle chiles in adobo sauce, minced, with 2 teaspoons sauce
Pinch of salt
Preheat oven to 350 degrees. Lightly coat a 9-by-5-inch meatloaf pan with nonstick cooking spray or oil.
In a small saucepan over medium heat, heat olive oil. When oil is hot, add onion and cook until just soft, 3-4 minutes. Add garlic and continue to cook until fragrant, about 1 minute.
Add chile powder, cumin and oregano and stir to combine. Continue cooking, stirring every so often, until mixture is very soft and slightly darkened, an additional 2 minutes.
Deglaze the pan by adding Worcestershire sauce and scraping up any brown bits from the bottom with a spatula. Transfer mixture to a large bowl and allow to cool slightly.