Dejah Wilson scored a season-high 27 points as the Chieftains improved to 4-1 with a home win.
Wilson scored 13 of her points in the first quarter, which ended with River leading 17-0.
Jordan Ryan had 13 points, nine rebounds and seven assists for the Chieftians.
Jasmine Morgan had 10 points to lead Seton Catholic (4-1).
COLUMBIA RIVER 64, SETON CATHOLIC 27
SETON CATHOLIC — Michaela Ephraim 2, Emma Watkins 3, Jasmine Morgan 10, Madi Manary 0, Maddie Willis 9, Jerrica Pachl 3, Hanna Jo Hammerstrom 0, Cailean McGovern 0, Annie Marichalar 0. Totals 9 (2) 7-13 27.
COLUMBIA RIVER — Grace Trickett 0, Dejah Wilson 27, Sami Myers 8, Lily Jones 0, Isabelle Fink 0, Bailey Gatten 5, Noelle Young 3, Emalee Place 0, Jordan Ryan 13, Ellie Christian 0. Totals 25 (10) 4-7 64.
