A 14-0 third quarter propelled the host Falcons to the win in the Class 3A Greater St. Helens League opener for both teams.
Natalie Whitesal scored a game-high 14 points for Prairie, which hit 10 3-pointers in the game compared with only one for Columbia River.
The Falcons (9-3, 1-0) led 30-20 at halftime, then pulled away in the third quarter. Prairie coach Brett Johnson said his team improved its intensity in the third period.
Cherita Daugherty had seven assists and seven rebounds for the Falcons. Kris Rocci grabbed eight rebounds and Grace Prom made three steals.