Natalie Whitesel had 16 points and 10 rebounds to lead Prairie to a non-league road win.
Macey Hsu added 14 points while Cherita Daughterty had seven points, eight rebounds, four assists and four steals.
Prairie (6-3) built a 36-23 advantage at halftime and led comfortably for the rest of the game. Jozie Tangeman had nine points and nine rebounds for the Falcons.
Madi Crews scored 26 points to lead Centralia.
PRAIRIE 70, CENTRALIA 57
PRAIRIE (6-3) — Sarina Martinez 0, Dejah Gobert 6, Cassidy Gardner 0, Kris Rocci 0, Jozie Tangeman 9, Mallory Williams 5, Grace Prom 13, Macey Hsu 14, Cherita Daugherty 7, Natalie Whitesel 16. Totals 25 (10) 10-15 70.
CENTRALIA — A. Fast 10, Crews 26, Blaser 2, Akins 0, Corwin 11, Alvair 0, M. Fast 8. Totals 21 (8) 7-16 57.
Prairie 20 16 21 13–70
Centralia 10 13 15 19–57
JV — Prairie won.