Five-time major champ Maria Sharapova is seeded fifth, meaning there’s a chance she could face Williams in the quarterfinals. The runner-up the last two years, Victoria Azarenka, is seeded 16th after an injury-plagued season.
Venus Williams is seeded 19th.
The draw is Thursday, and the tournament starts Monday.
U.S. OPEN WOMEN’S SEEDS:
1, Serena Williams, United States
2, Simona Halep, Romania
3, Petra Kvitova, Czech Republic
4, Agnieszka Radwanska, Poland
5, Maria Sharapova, Russia
6, Angelique Kerber, Germany
7, Eugenie Bouchard, Canada
8, Ana Ivanovic, Serbia
9, Jelena Jankovic, Serbia
10, Caroline Wozniacki, Denmark
11, Flavia Pennetta, Italy
12, Dominika Cibulkova, Slovakia
13, Sara Errani, Italy
14, Lucie Safarova, Czech Republic
15, Carla Suarez Navarro, Spain
16, Victoria Azarenka, Belarus
17, Ekaterina Makarova, Russia
18, Andrea Petkovic, Germany
19, Venus Williams, United States
20, Svetlana Kuznetsova, Russia
21, Sloane Stephens, United States
22, Alize Cornet, France
23, Anastasia Pavlyuchenkova, Russia
24, Sam Stosur, Australia
25, Garbine Muguruza, Spain
26, Sabine Lisicki, Germany
27, Madison Keys, United States
28, Roberta Vinci, Italy
29, Casey Dellacqua, Australia
30, Barbora Zahlavova Strycova, Czech Republic
31, Kurumi Nara, Japan
32, Zhang Shuai, China