Ryan Kukula scored 24 points to lead the visiting Fishermen to the 1A Trico League win.
The Cougars got within one point in the fourth quarter, but Ilwaco made free throws down the stretch to clinch the win.
Cole Farrell had 16 points, Justin James scored 15 and William Noce-Sheldon 12 for Seton Catholic.
ILWACO 68, SETON CATHOLIC 60
ILWACO — Ryan Kukula 24, Wilson 16, Sheldon 7, Milligan 0, Weidner 8, Lee 0, Gonzales 10, McMillan 3, Adams 0, Hernandez 0. Lopez 0. Totals 24 (8) 12-21 68.
SETON CATHOLIC — Evan Sims 9, Cole Farrell 16, DK Lee 2, Drew Fuller 0, Pat Grace 1, Justin James 15, William Noce-Sheldon 12, CJ Strong 2, Riley McShane 3. Totals 18 (6) 18-23 60.