A big third quarter helped the Indians hand the visiting Wildcats their first loss.
Toledo outscored La Center 18-7 in the third period of the Trico League game to build a seven-point lead, and the Wildcats never regained a lead.
La Center had a chance to win at the buzzer, but a shot and several tip-in attempts failed to fall.
Will Rice scored 13 points and Brody Seter 12 for the Wildcats, who were outscored 10-2 from the foul line. Forrest Wallace led Toledo with 17 points.
TOLEDO 45, LA CENTER 44
LA CENTER (2-1, 2-1) — Connor Wonderly 2, Chase Davison 4, Jonathan Griffee 2, Wyatt Aguirre 6, Matt Braaten 5, Brody Seter 12, Will Rice 13, Mason Parmatier 0, Sean Nolan 0. Totals 18 (6) 2-4 44.